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Physics meets biology and finds new challenges,
spinning off the new subject area of biotechnology. Biotechnology
promises an increase in the human "health-span" with new
devices to fight disease, replace defective body parts and reduce
time in hospital following injury.
We
have projects in the development of new materials for prosthetics
and coatings for body implants which improve their performance in
the body. A current focus is the development of a bio-compatible
coating to increase the wear resistance of a new synthetic heart
pump.
>
New Materials for Prosthetics
This
work is done in collaboration with the University of New South
Wales (Professor C.R. Howlett and Dr H. Zreiquat). We have support
from the ARC to develop materials and systems for recruiting bone
cells and promoting their growth on artificial surfaces. This
development will reduce the hospitalization time of patients requiring
skeletal or joint repair following fracture or injury. We plan
a new project to investigate the feasibility of seeded trenches
produced by lithographic methods for selective recruitment of
bone cells.
> Bio-compatible
Wear Resistant Coatings
This
work is supported by the ARC SPIRT scheme and is a joint venture
between the University of Sydney (Professors D.R. McKenzie, M.V.
Swain and Mr R. Tarrant) and Ventrassist, a development company
(Dr. N. James). We are developing low friction coatings with high
bio-compatibility based on carbon. The challenge is to produce
coatings with extreme levels of adhesion which are also thick.
These coatings play a vital role in the new Ventrassist heart
replacement pump.
> Bio-Optics
The
living world provides a multitude of examples of the clever use
of light for vision camouflage, courtship and signalling. The
research is part of a collaborative program between Professor
D. R. McKenzie of the University of Sydney, Dr Maryanne Large,
and Dr Andrew Parker originally from the Australian Museum in
Sydney. Of particular interest is the use of structure to achieve
reflections and colour effects, as an alternative to pigmentation.
Structural colours are produced by such processes as scattering,
interference effects and diffraction. These mechanisms can be
found in many natural systems and seem to be particularly important
in marine organisms, because their high reflectivity means that
they can function efficiently in low light levels. Publications
of the Bio-Optics group discuss the use of broad-band reflectors
and the use of laminar structures. Randomness or "chaotic" structures
are used in clever ways to produce effects which are difficult,
even today, to reproduce by artificial means.
The
Secret Light of Beetles: The "metallic" reflectors in Christmas
beetles are composed of multiple layers of high and low refractive
index materials, with randomised spacings. This gives a high reflectance
over a broad spectral range- a method also employed in the shiny
skin of fish. These may be used in conjunction with scattering
or thin film effects.
 
Christmas
beetles (left) and SEM of a cross section through the cuticle
of a beetle (right).
For further
information on any of the above research fields, please contact
Prof. David McKenzie, d.mckenzie@physics.usyd.edu.au.
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