Applications
Numerous applications of our modeling efforts to experimental and clinical data have been made,
including:
- Determining the physiological parameters of normal subjects,
and verifying these against independent measurements, partly
as a test of the model.
- Studying parameter changes with age in normal subjects.
- Studying parameter changes with arousal and attention, including
sleep-related analyses.
- Interrelating multiple measures within a model-based framework
- e.g., EEGs, Evoked Potentials, and fMRI.
- Exploring physiological parameter shifts in disorders, medicated
and unmedicated, including ADHD, Parkinson's disease, schizophrenia,
and Alzheimer's.
- Use of the model to extract physiological parameters from electrophysiological
data noninvasively. This has resulted in extensive collaborations
with the Brain Resource Company, including use of its International
Brain Database and development of intellectual property.
Current Research Projects
- Modulations associated with sleep
- Additional subcortical structures
- Modulations associated with
stimulus processing
- Modeling of the cortex-scalp
transfer function
- Numerical modeling of inhomogeneities
and anisotropies
- Modeling of fMRI signals
Key Publications
Robinson, P. A., Rennie, C. J., and Wright, J. J. (1997). Propagation
and Stability of Waves of Electrical Activity in the Cerebral
Cortex, Physical Review
E, 56, 826-840.
Rennie, C. J., Robinson, P. A., and Wright, J. J. (2002).
Unified Neurophysical Model of EEG Spectra and Evoked Potentials},
Biol.
Cybernetics, 86, 457-471.
Robinson, P. A., Rennie, C. J., and Rowe, D.
L. (2002). {\it Dynamics of Large-Scale Brain Activity in Normal
Arousal States and
Epileptic Seizures, Physical Review E, 65, 041924, 1-9.
Robinson, P. A., Rennie, C. J., Rowe, D. L., and O'Connor, S.
C. (2004). Estimation of Multiscale Neurophysiological Parameters
by EEG Means: Consistency and Complementarity vs. Independent Measures,
Human
Brain Mapping, 23, 53-72.
Rowe, D. L., Robinson, P. A., and Rennie,
C. J. (2004). Estimation of Neurophysiological Parameters from
the Waking EEG Using a Biophysical Model of Brain Dynamics, Journal
of Theoretical Biology, 231, 413-433.
Rowe, D. L., Robinson. P. A., Harris, A. W., Felmingham, K. L.,
Lazzaro, I. L.,
and Gordon, E. (2004). Neurophysiologically-Based Mean-Field
Modeling of Tonic Cortical Activity in
Post-traumatic Stress Disorder (PTSD), Schizophrenia, First Episode
Schizophrenia (FESZ), and
Attention Deficit Hyperactivity Disorder (ADHD), Journal of Integrative
Neuroscience, 3, 453-487.
O'Connor, S. C., and Robinson, P. A. (2005). Analysis of
the EEG Activity
Associated with Thalamic Tumors, Journal of Theoretical Biology,
233, 271-286.
Rowe, D. L., and Robinson, P. A. (2005). Stimulant Drug Action
in
Attention Deficit Hyperactivity Disorder (ADHD): Inference of Neurophysiological
Mechanisms via Quantitative Modeling}, Clinical Neurophysiology,
116, 324-335.
Hole, M. J., Robinson, P. A., and Cairns, I. H. (2005). Statistics
of
Polarization and Stokes Parameters: Multiple Orthonormal Wave Populations,
Physical Review E,
submitted.
|